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  • 18 Comments
Joined 1 year ago
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Cake day: June 12th, 2023

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  • DRx@lemmy.worldtoADHD memes@lemmy.dbzer0.comGetting up to speed
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    3 months ago

    Well, as a pharmacist whose been stable on 50mg of vyvanse for more than 3 years, your wife and Doc are both incorrect…

    Both are stimulants, yes, but

    Vyvanse is an amphetamine and works to produce more neurotransmitters you don’t already have.

    Cocaine is a reuptake inhibitor… thus preventing the breakdown of neurotransmitters you do already have.

    While fundamentally they may look like they’re doing the same thing, they are in fact 2 totally different mechanisms. Furthermore, in neurotransmitter depletion the effects of cocaine will severely diminish, where as amphetamines will thrive.



  • DRx@lemmy.worldtoMemes@lemmy.ml6÷2(1+2)
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    7 months ago

    Def not a math major (BS/PharmD), but your explanation was like seeing through a visual illusion for the first time! lol

    I was always taught PEMDAS growing up, and that the MD and the AS was read left to right in an equation like above. But stating the division as a fraction completely changes my mind now about how this calculation works. I think what would happen in a calculation I use every day if the former was used.

    Example: Cockcroft-Gault Equation (estimation of renal function)

    (140-age)(kg) / 72(SCr) vs (140-age) X kg ➗72 X SCr

    In the first eq (correct one) an 80yo patient who weighs 65kg and has an SCr ~ 1.5 = 36.11

    In the latter it = 81.25 (waaay too high for an 80yo lol)

    edit: calculation variable



  • So unless you live in an area with fiber, asymmetrical speeds are pretty typical… I’m not sure if it is because it’s all coax so there are infrastructure limitations? But it’s actually gotten faster because 6 months ago my upload was only 30 mbit/s.

    Once fiber is in my area I’ll switch to that, but symmetrical will add more cost…but of course it will lol




  • No, not aspirin. We know aspirin very well in the medical community.

    TBF there are drugs out there that we do not know the MOA of, like methocarbamol (from the national institute of health: “The exact mechanism of action of methocarbamol remains unknown; similarly unknown is the relationship between musculoskeletal pain and muscle spasm” lol)

    So for long term safety, it is based on animal and human studies. These studies happen for multiple years prior to being put on the market (for the most part, though that is a story for a different day). Then after the drug is on the market, the drug company is required to do “Postmarket Clinical Studies” to show that their drug is still doing what it was initial shown to do; furthermore, to look for safety events of said drug.

    A really famous case of a bungled postmark study was Vioxx. Vioxx is/was a Cox-2 specific pain medication. In the initial and postmarket studies they found that it had an increased risk of heart attack (in some cases up to 88% increased risk). The company Merck held the information from the public and FDA. They were forced to take the drug off the market in 2004. Technically in short bursts Vioxx was probably safe, but long term it was not.


  • Well how specific is enough to say we do or don’t know how a drug works?

    In particular we do know that ASA and other NSAIDS work by inhibiting the activity of the enzyme called cyclooxygenase which leads to the formation of prostaglandins that cause inflammation, swelling, pain and fever. It blocks both COX 1 and 2, though only COX 2 is responsible inflammation. Furthermore, The antithrombotic action of aspirin is due to inhibition of platelet function by acetylation of the platelet cyclooxygenase at the functionally important amino acid serine529.

    Now contrast ASA with Acetaminophen …

    We know that Acetaminophen also inhibits COX, but only in the CNS and not peripherally. Also, it is only thought that it potentially blocks pain signals via the serotonergic pain pathway.

    I would say we know a hell of a lot about aspirin … Acetaminophen not so much on the MOA side of things, however it has been studied so much that we know the safety/toxicity profile like the back of our hands. Either way probably not the best 2 examples to use for your argument.





  • Christian brings up some great points worthy of consideration; however, if your going to use traditional routing through their network (A/cname) your still doing the same thing. CF will still see your traffic.

    The second thing I should say is, I only use zero trust for websites I share with family. So, I have a Searxng and wef/voyager dockers running through zero trust.

    For admin, homeassistant/iot/ip cams, I use an always on IPSec vpn on my iPhone, iPad, and steam deck (take it to work and plug into 3rd monitor) … this is cool because I get 24/7 ad blocking no matter where I am because it routes all my traffic through my pihole at home. This is a great solution for a single person, but I do not want to manage vpn access for multiple ppl. So, I agree with christian in NOT putting admin stuff/sensitive info behind CF at all (zero trust OR tradition web routing) unless you fully trust them. Otherwise do a 24/7 vpn like I do.



    1. Parents are southern baptist and tithe 10% yearly

    2. Constantly complain about socialism, and taxes

    3. Go on mission trips to Haiti to help build homes

    4. Constantly complain about refugees and immigration

    5. Claims to have lgbt, black, etc minority friends

    6. Sees nothing wrong with current Supreme Court trend taking rights away from said minority groups…

    7/8. Think of any two things that are opposites between real life, what religion should be about, and politics… and it is someway twisted in a way you wouldn’t think would be possible.

    TLDR: there is no way of dealing with this cognitive dissonance. It is maddening. I’ve gotten to the point of trolling my fam with republican Jesus lol. It’s the only thing that makes me at least laugh about the insanity.




  • I like android and have a couple android devices (mostly retro handhelds and CCTV, and have spun up a few VMs), I also have many devices with linux (unraid, pihole, vpn servers, web servers) and run a pfsense firewall (FreeBSD), AND my gaming PC is windows…

    I say all that because when it comes to mobile devices, however, I am all in pretty much on apple. Phone, watch, Pro 2s, and Ipad mini go with me pretty much every where. Why? not really the app eco-system (because I do so much self-hosting and use a lot of PWAs, and I dont play games on my phone), its the inter-operability between all the devices, its the find my device, Its the earpods going from my ipad to my iphone in an instant, Its the battery life, its (for the most part) security of the devices.

    The blue/green bubble thing is weird and I don’t understand why people get so upset over it. I use everything, and to be honest the only thing at this point in my life I would like to get rid of is windows, but I can’t yet because of gaming.


  • SteamDeck Settings:

    1. 60fpsBlackscreenfix
    2. DynamixFPS++30_totk
    3. Graphics - Disable LOD Quality Reduction
    4. Graphics - Shadows - 512x - performance boost
    • Yuzu settings under totk properties
    1. CPU - Unsafe (leave all boxes checked)
    2. Graphics -
    • api: vulkan
    • Use Disk pipline, Use asynch GPU, and Accelerate ASTC all enabled
    • Window Adapting = Bilinear
    • AA method = none
    1. Adv Graphics
    • Accuracy = normal

    • Only items enabled on mine = Reactive flushing, use asynch shader block, and use vulkan pipeline cache